4/4/2023 0 Comments Transcribe 8 license key full![]() ![]() Aging in murine liver is characterized by an increase in chromatin accessibility at promoter regions, but not in an increase in transcriptional output. We provide the first systematic inventory of the connection between aging, chromatin accessibility, and transcriptional regulation in a whole tissue. Here, we used a multi-omics approach and integrated ATAC-, RNA- and NET-seq to identify age-related changes in the chromatin landscape of murine liver and to investigate how these are linked to transcriptional regulation. However, little is known about the changes in the level of transcriptional regulation. ![]() With age, chromatin alterations occur on all levels of genome organization, accompanied by changes in the gene expression profile. Regulation of gene expression is linked to the organization of the genome. ![]()
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